It is with great sadness that we report the death of Raphael Mechoulam, PhD, of blessed memory, the acclaimed “Father of Cannabinoid Science” at age 92 in Jerusalem. Born in Sophia, Bulgaria to a Sephardic Jewish family in 1930, he had to flee the country in World War II to emigrate to Palestine. As a young scientist, “Raphi” as he was known to all his colleagues and friends, began his work on cannabis by reporting the correct structure of cannabidiol (CBD) in 1963. This was followed by the discovery and synthesis of tetrahydrocannabinol (THC) in 1964, and that of many other phytocannabinoids. While these accomplishments would have been sufficient evidence of a brilliant career, his discoveries never ceased, and included early clinical work on cannabis compounds in the 1970s, the discovery in his laboratory of the endocannabinoids anandamide and 2-arachidonylglycerol, and description of the entourage effect in the 1990s. He remained active in research, publishing and lecturing until the end of his life, and was a mentor to countless scientists the world over.   Beyond that, Raphi was a Renaissance man, knowledgeable on innumerable subjects and extremely generous with his time and teaching. On a personal note, Raphi was extremely kind to me from our first meeting in Acapulco at the ICRS meeting in 1999, where we bonded over our common ancestry (my family were Sephardim from Macedonia and neighbors to his in Bulgaria) and belief in the therapeutic value of cannabis and cannabinoids. He was my mentor and surrogate uncle for 24 years. He will be dearly missed. The world has lost a great man and inspirational leader. #RaphaelMechoulam Pictured: Ethan Russo with Raphael Mechoulam and Yehiel Gaoni, the discoverers of THC, in Jerusalem, 2010 on the occasion of Raphi’s 80th birthday. Photo by Fred Gardner.